An arteether injection for treatment of malaria.

摘要

Malaria is a vector borne infectious disease caused by protozoan parasites. Oil based arteether injections are used as anti-malarial drugs, specifically for the treatment of chloroquine resistant Plasmodium falciparum malaria and cerebral malaria cases. Arteether is a fast acting blood schizontocide. The injectable formulation of arteether contains a mixture of ethyl oleate and ethyl alcohol in specific concentrations to reduce the viscosity and the filling volume of the product. This creates minimum muscle pain and muscle stiffness because a higher concentration of arteether (150 mg) is present in a small volume of injectable solution (1 ml). Other pharmaceutical excipients like antioxidants and preservatives are also used in the formulation.