QUINOLINE DERIVATIVES AS ANTIBACTERICAL AGENTS

摘要

The present invention relates to use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib), a pharmaceutically acceptable acid or base addition salt thereof, a quaternary amine thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein Ris hydrogen, halo, alkyl or pyridinyl; p is 1, 2 or 3; Ris hydroxy; alkyloxy optionally substituted amino or mono or di(alkyl)amino or a radical structure of which is given in description; mono or di(alkyl)amino, wherein alkyl may optionally be substituted by one or two substituents, each independently be selected from alkyloxy or phenyl, or morpholinyl, or 2-oxopyrrolidiny; phenyl; Het or a radical structure of which is given in description; Ris Ar Het; q is zero, 1, 2, 3 or 4; X is a direct bond or CH; Rand Reach independently is alkyl; Ris hydrogen or a radical structure of which is given in description; Ris hydrogen or alkyl; Ris hydrogen or phenyl; Ris hydrogen; Ris oxo; Ris alkyl, hydroxyl, aminocarbonyl, Ar, Het, alkyl substituted with one or two Het, alkyl substituted with one or two phenyl groups, Het-C(=O)-, alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms ; or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms; wherein each carbon atom can be optionally substituted with hydroxy, alkyloxy or oxo; Ar is a homocycle selected from the group of phenyl or naphthyl, each optionally substituted with 1, 2 or 3 substituents, each substituent independently selected from the group of halo or alkylcarbonyl; Het is a monocyclic heterocycle selected from the group of imidazolyl, furanyl, thienyl, thiazolyl, pyridinyl; or a bicyclic heterocycle selected from the group of 1,2,3,4-tetrahydroisoquinolinyl, benzofuranyl, or benzo[1,3]dioxolyl; halo is a substituent selected from the group of fluoro, chloro, bromo and iodo provided that when Ris hydrogen then the radical may also be placed in position 4 of the quinoline ring.