| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: described is a method of producing a compound of general formula I where R1 denotes a radical of formula II: where R2 is a protective tetrazole group which is a novel intermediate compound when producing losartan - 2-n-butyl-4-chloro-5-hydroxymethyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4]methyl}-imidazole, and a method of producing losartan based on compound I by reducing the formyl group and then adding a chlorine atom to the imidazole ring and removing the protective R2 group. ^ EFFECT: method ensures high output of the end product from available starting and intermediate compounds on an industrial scale. ^ 9 cl |
