Genetic products differentially expressed in tumors and the use thereof

摘要

Disclosed is a pharmaceutical composition, comprising one or more components selected from the group consisting of: (i) a tumour-associated antigen or a functional fragment thereof; (ii) a nucleic acid which codes for a tumour-associated antigen or a functional fragment thereof; (iii) an antibody which binds to a tumour-associated antigen or a functional fragment thereof; (iv) an antisense nucleic acid which hybridizes specifically with a nucleic acid coding for a tumour associated antigen; (v) an isolated host cell which expresses a tumour associated antigen or a functional fragment thereof; and (vi) isolated complexes between a tumour-associated antigen or a functional fragment thereof and an HLA molecule. The tumour-associated antigen disclosed in (i)-(vi) has a sequence encoded by a nucleic acid which is selected from the group consisting of: a) a nucleic acid which comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO: 84, as defined in the specification, a fragment thereof, wherein said fragment thereof encodes a functional fragment of the tumour-associated antigen encoded by the nucleic acid sequence, b) a nucleic acid which hybridizes with the nucleic acid of a) under stringent conditions, c) a nucleic acid which is degenerate with respect to the nucleic acid of a) or b), and d) a nucleic acid which is complementary to the nucleic acid of a), b) or c).