摘要 |
Disclosed is a compound of formula (I) wherein the template contains DPro-LPro or LPro-DPro and Z is a chain of 12 alpha-amino acids whereby the amino acids at positions P1 to P12 of the chain are: P1: Ala, Cit, Thr, Asp, Glu; P2: Trp, Tyr; P3: Ile, Cal, Nle, Chg, Cha; P4: Dab, Lys, Gln; P5: Lys, Dab, Orn; P6: Dab, DDab, Lys; P7: His, Lys, Gln, Dab; P8: Tyr, Trp, Ser; P9: Dab, Lys; P10: Dab, Lys; P11: Ala, Abu, Thr, Gly, Pro, Hse, Ile, Nva, DAla, DVal, Aib, Nle, Chg, Cha, Gln, Asp, Glu, Cpa, t-BuG, Leu, Val, Asn; and P12: Dab, Lys, Gln, Ser. The document further discloses uses of said compounds in the manufacture of a medicament for treatment or prevention of infections or related diseases thereof, said compound is further disclosed to be used as a disinfectant or preservative. |
申请人 |
POLYPHOR LTD.;UNIVERSITAT ZURICH |
发明人 |
GOMBERT, FRANK;OBRECHT, DANIEL;VRIJBLOED, WIM;DIAS, RICARDO;DEMARCO, STEVE J;ROBINSON, JOHN ANTHONY;SRINIVAS, NITYAKALYANI |