Modified human growth hormone polypeptides and their uses

摘要

Disclosed is a human growth hormone (hGH) polypeptide comprising a non-naturally encoded amino acid (NEAA) comprising a carbonyl functional group, wherein said NEAA is positioned at a following position of hGH comprising the amino acid sequence set forth in SEQ ID NO:2: (i) at the N-terminus; (ii) within residues 10-31; (iii) within residues 35-74; (iv) within residues 86-95; (v) within residues 97-102; (vi) within residues 111-119; (vii) within residues 134-146; (viii) within residues 155-176; and (ix) at the C-terminus.