摘要 |
Disclosed is a method of preparing a drug targeting system for administering a pharmacologically active substance to the central nervous system of a mammal across its blood brain barrier, the method comprising the steps of: a) solubilising poly(DL-lactide) and/or poly(DL-lactide-co-glycolide), at least one pharmacologically active substance, and a liquid compound selected from the group of lipid compounds which consists of cetyl phosphate, potassium cholesteryl sulphate and tocopheryl succinate, in an organic solvent to obtain an organic phase; b) pouring the organic phase into an aqueous solution; c) emulsifying the mixture to obtain a primary emulsion; d) homogenising the primary emulsion; e) removing the organic solvent from the primary emulsion; f) filtering the resulting nanosuspension comprising drug-loaded nanoparticles; and g) coating the nanoparticles with poloxamer 188. Also disclosed is a drug targeting system which comprising nanoparticles made of poly(DL-lactide) and/or poly(DL-lactide-co-glycolide) , and at least one pharmacologically active substance being absorbed to, adsorbed to, and/or incorporated into the nanoparticles, wherein the system comprises a poloxamer 188 surfactant coating deposited on the drug-loaded nanoparticles, and wherein the system has been prepared in accordance with the above method or an analogous method as disclosed herein.
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