| 摘要 |
<p>Disclosed is a percutaneous absorption preparation of a basic anti-dementia drug used as a plaster to skin, which comprises at least an adherent layer, an intermediate membrane, and a drug reservoir layer sequentially from the side which is plastered on skin, wherein: said drug reservoir layer comprises a basic antidementia drug or a salt thereof; a dialkylaminoalkyl(meth)acrylate-alkyl(meth)acrylate copolymer; a polyhydric alcohol selected from a sugar alcohol and a glycol; a carboxylic acid ester selected from an alkyl citrate ester and an alkyl sebacate ester; a sorbitan fatty acid ester; and a (meth)acrylate-vinyl ester copolymer, said intermediate membrane is a microporous membrane having pores which allow permeation of the basic antidementia drug, and said adherent layer enables the plastering of the percutaneous absorption preparation to skin, is permeable to the basic antidementia drug, and comprises a carboxylic acid ester selected from an alkyl citrate ester and an alkyl sebacate ester; a sorbitan fatty acid ester; and a (meth)acrylate-vinyl ester copolymer.</p> |
