Mutation in OAS1 genes

摘要

Provided is an oligoadenylate synthetase 1 protein comprising a polypeptide having a specified amino acid sequence with at least one amino acid modification at position 1, 24, 25, 28, 31, 36, 47, 53, 54, 64, 69, 74, 104, 108, 112, 113, 114, 115, 116, 117, 118, 119, 127, 130, 139, 142, 160, 161, 162, 166, 175, 179, 226, 242, 246, 248, 250, 254, 274, 279, 282, 284, 288, 289, 292, 295, 314, 315 and 335. Further provided are corresponding antisense and RNAi molecules, ribozymes and antibodies. The compositions are useful in treating viral diseases.