发明名称 QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
摘要 Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
申请公布号 US2011046110(A1) 申请公布日期 2011.02.24
申请号 US20090990339 申请日期 2009.04.30
申请人 VU CHI B;DISCH JEREMY S;SPRINGER STEPHANIC K;BLUM CHARLES A;PERNI ROBERT B 发明人 VU CHI B.;DISCH JEREMY S.;SPRINGER STEPHANIC K.;BLUM CHARLES A.;PERNI ROBERT B.
分类号 A61K31/538;A61K31/439;A61K31/4709;A61K31/497;A61K31/498;A61K31/501;A61K31/506;A61K31/5377;A61P3/00;A61P3/10;A61P5/50;C07D215/40;C07D215/48;C07D401/12;C07D405/12;C07D413/14;C07D417/12;C07D417/14;C07D453/02 主分类号 A61K31/538
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