发明名称 LABELLED ANALOGUES OF HALOBENZAMIDES AS MULTIMODAL RADIOPHARMACEUTICALS AND THEIR PRECURSORS
摘要 A compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydrogen atom, a (C1-C4) alkyl group or forms together with the group R1—Ar a ring fused with the Ar group, A represents a group of formula (β) or (δ): R3 and R4 independently represent a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6) alkenyl group or a group of formula (y): wherein R11 represents an optionally labelled halogen, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen, a radionuclide, a—NO2 group, a—NR5R6 group, a N+R5R6R7X−group, or a—OSO2R12 group, and their addition salts with pharmaceutically acceptable acids.
申请公布号 US2011044899(A1) 申请公布日期 2011.02.24
申请号 US20090865059 申请日期 2009.01.28
申请人 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIESALTERNATIVES;UNIVERSITE D'AUVERGNE CLERMONT 1;LABORATOIRES CYCLOPHARMA 发明人 CHEZAL JEAN-MICHEL;DOLLE FREDERIC;MADELMONT JEAN-CLAUDE;MAISONIAL AURELIE;MIOT-NOIRAULT ELISABETH;MOINS NICOLE;PAPON JANINE;KUHNAST BERTRAND;TAVITIAN BERTRAND;BOISGARD RAPHAEL
分类号 A61K51/00;A61K31/437;A61K31/4375;A61K31/44;A61K31/4709;A61K31/473;A61K31/498;A61K31/555;A61P35/00;A61P43/00;C07D213/65;C07D241/44;C07D401/12;C07D471/04;C07F7/22 主分类号 A61K51/00
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