发明名称 |
TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS |
摘要 |
<p>Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N-H, N-(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110d, and therefore have utility in therapy.</p> |
申请公布号 |
WO2011021038(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
WO2010GB51370 |
申请日期 |
2010.08.19 |
申请人 |
KARUS THERAPEUTICS LIMITED;SHUTTLEWORTH, STEPHEN JOSEPH;CECIL, ALEXANDER RICHARD LIAM;HILL, THOMAS JAMES;SILVA, FRANCK ALEXANDRE |
发明人 |
SHUTTLEWORTH, STEPHEN JOSEPH;CECIL, ALEXANDER RICHARD LIAM;HILL, THOMAS JAMES;SILVA, FRANCK ALEXANDRE |
分类号 |
C07D495/14;A61K31/519;A61P35/02;C07D491/147;C07D519/00 |
主分类号 |
C07D495/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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