发明名称 |
REPROGRAMMING A CELL BY ACTIVATION OF THE ENDOGENOUS TRANSCRIPTION FACTOR NETWORK |
摘要 |
The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises delivering a transcription factor to a cell and exposing said cell to an agent that inhibits the activity, expression, or activity and expression of a gene, which codes for a protein, or a protein involved in transcriptional repression, and selecting a cell, wherein differentiation potential has been restored to said cell. In yet another embodiment, the invention relates to a reprogrammed cell and an enriched population of reprogrammed cells that can have characteristics of an ES-like cell can be re- or trans-differentiated into various differentiated cell types. |
申请公布号 |
WO2011022413(A2) |
申请公布日期 |
2011.02.24 |
申请号 |
WO2010US45777 |
申请日期 |
2010.08.17 |
申请人 |
NUPOTENTIAL, INC.;EILERTSEN, KENNETH, J.;RIM, JONG, S.;POWER, RACHEL, A.;STASZKIEWICZ, JAROSLAW |
发明人 |
EILERTSEN, KENNETH, J.;RIM, JONG, S.;POWER, RACHEL, A.;STASZKIEWICZ, JAROSLAW |
分类号 |
C12N5/10;C12N5/02;C12N5/074;C12N15/12 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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