发明名称 |
HETEROLOGOUS EXPRESSION OF EXTREMOPHILE HEAT SHOCK PROTEINS AND CHAPERONES IN MICROORGANISMS TO INCREASE TOLERANCE TO TOXIC COMPOUNDS |
摘要 |
The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as γ-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
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申请公布号 |
US2011045554(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
US20080528620 |
申请日期 |
2008.02.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
CLARK DOUGLAS S.;WHITEHEAD TIMOTHY;ROBB FRANK T.;LAKSANALAMAI PONGPAN;JIEMJIT ANCHALEE |
分类号 |
C12P7/64;C12N1/00;C12N1/13;C12N1/15;C12N1/19;C12N1/21;C12N15/63;C12N15/70;C12N15/74;C12N15/80;C12N15/81;C12P1/00;C12P1/02;C12P1/04;C12P5/00;C12P7/06;C12P7/16;C12P7/26 |
主分类号 |
C12P7/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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