发明名称 |
VARIANT IMMUNOGLOBULINS WITH IMPROVED MANUFACTURABILITY |
摘要 |
<p>This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.</p> |
申请公布号 |
CA2771465(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
CA20102771465 |
申请日期 |
2010.08.20 |
申请人 |
LONZA BIOLOGICS PLC |
发明人 |
ARNELL, ANDREAS;JIMENEZ, JOSE;MICHAEL, REBECCA;STALLWOOD, YVETTE;ZURDO, JESUS |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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