发明名称 |
PHARMACEUTICAL COMPOSITION CONTAINING TRANSIENTLY SURVIVING CTL |
摘要 |
Disclosed are transplantation cells for an immunotherapy, which are applicable to a wider variety of patients compared to conventional transplantation cells for immunotherapies, and which can survive transiently so that severe GVH disease cannot be induced. Specifically disclosed is a pharmaceutical composition containing cells derived from human hematopoietic stem cells. In the pharmaceutical composition, the genetic locus of at least one human HLA class I molecule in the cells contains at least one antigen for which the type of matching of the cell is identical to that of a patient. The genetic locus of each of the human HLA class I and II molecules in the cells contains at least one antigen for which the type of matching of the cell is not identical to that of a patient, and the cells derived from the hematopoietic stem cells do not cause acute GVH disease having a severity of level III or IV in the body of a patient even when the cells survive in the patient permanently. |
申请公布号 |
WO2011021503(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
WO2010JP63181 |
申请日期 |
2010.08.04 |
申请人 |
THE UNIVERSITY OF TOKYO;YAMASHITA, NAOHIDE;NAGAYAMA, HITOMI;FUJITA, SHIGEHARU |
发明人 |
YAMASHITA, NAOHIDE;NAGAYAMA, HITOMI;FUJITA, SHIGEHARU |
分类号 |
A61K35/28;A61K35/14;A61K35/44;A61P31/00;A61P35/00 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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