| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for producing optically active L- or D-tert-leucine important as a raw material for medicines and agrochemicals, which is excellent in operability and can industrially be performed. <P>SOLUTION: In the method for producing optically active tert-leucine, including treating tert-leucine amide with a biological catalyst capable of stereoselectively hydrolyzing tert-leucine amide in an aqueous solution containing acid radicals, adding a base to the reaction solution, and then displacing the solvent of the reaction solution from water to a poor solvent of the optically active tert-leucine to deposit and take out the produced optically active tert-leucine, acetic acid radical among the acid radicals in a liquid added for the solvent displacement is 45 mol% or more, and the poor solvent is an alcohol. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
