发明名称 |
POLYNUCLEOTIDES ENCODING A FEEDBACK RESISTANT ASPARTOKINASE FROM CORYNEBACTERIUM |
摘要 |
The invention provides methods to increase the production of an amino acid from Corynebacterium species by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome. The invention also provides novel processes for the production of an amino acid by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome and/or by increasing promoter strength. In a preferred embodiment, the invention provides processes to increase the production of L-lysine in Corynebacterium glutamicum by way of the amplification of L-lysine biosynthetic pathway genes in a host cell chromosome. The invention also provides novel isolated nucleic acid molecules for L-lysine biosynthetic pathway genes of Corynebacterium glutamicum.
|
申请公布号 |
US2011045549(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
US20100772538 |
申请日期 |
2010.05.03 |
申请人 |
HANKE PAUL D;LI-D ELIA LHING-YEW;WALSH HOLLY J;CRAFTON COREY M;RAYAPATI P JOHN |
发明人 |
HANKE PAUL D.;LI-D'ELIA LHING-YEW;WALSH HOLLY J.;CRAFTON COREY M.;RAYAPATI P. JOHN |
分类号 |
C12N15/09;C12P13/08;C07H21/00;C07K14/34;C07K14/345;C12N1/21;C12N9/12;C12N9/88;C12N15/52;C12N15/54;C12N15/63;C12N15/77;C12P13/04;C12R1/13 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|