发明名称 |
A PROCESS FOR THE SYNTHESIS OF NARATRIPTAN |
摘要 |
<p>The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.</p> |
申请公布号 |
CA2770178(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
CA20102770178 |
申请日期 |
2010.08.18 |
申请人 |
CIPLA LIMITED |
发明人 |
RAO, DHARMARAJ RAMACHANDRA;KANKAN, RAJENDRA NARAYANRAO;CHIKHALIKAR, SANDIP VASANT;GHAGARE, MARUTI |
分类号 |
C07D401/04;A61K31/404;A61K31/405 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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