摘要 |
The present invention provides a novel diazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The present invention relates to a diazepine compound represented by General Formula (1) or a salt thereof, wherein R1, R2, R3, and R4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y1 and Y2 are each independently -N= or -CH=; and R5 is group represented by (2) wherein R6 and R7 are each independently hydrogen or organic group; R6 and R7 may be linked to form a ring together with the neighboring group -XA-N-XB-; XA and XB are each independently a bond, lower alkylene, etc. |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
OSHIMA, KUNIO;MATSUMURA, SHUUJI;YAMABE, HOKUTO;ISONO, NAOHIRO;TAKEMURA, NORIAKI;TAIRA, SHINICHI;OSHIYAMA, TAKASHI;MENJO, YASUHIRO;NAGASE, TSUYOSHI;UEDA, MASATAKA;KOGA, YASUO;NAKAYAMA, SUNAO;TSUJIMAE, KENJI;ONOGAWA, TOSHIYUKI;TAI, KUNINORI;ITOTANI, MOTOHIRO |