The present invention relates to a process for preparing naratriptan or a salt thereof, the process comprising: (a) reacting a compound of formula (3) with a compound of the formula HCCR wherein Z is a protecting group, Y is a leaving group and R is a trialkyl silyl group, a trialkylstannyl group or a zinc (II) halide, to obtain the compound of formula (4); (b) converting the compound of formula (4) to a compound of formula (5) wherein Z' is hydrogen or a benzyl group; (c) converting the compound of formula (5) to naratriptan; and (d) optionally converting naratriptan to a salt thereof. The present invention also provides novel compounds (3) and (4) and processes for their preparation.
申请公布号
WO2011021000(A2)
申请公布日期
2011.02.24
申请号
WO2010GB01562
申请日期
2010.08.18
申请人
CIPLA LIMITED;RAO, DHARMARAJ RAMACHANDRA;KANKAN, RAJENDRA NARAYANRAO;CHIKHALIKAR, SANDIP VASANT;GHAGARE, MARUTI;CURTIS, PHILIP ANTHONY