A PROCESS FOR PREPARING BIARYL COMPOUNDS IN A SUZUKI TYPE REACTION ALLOWING PRODUCT ISOLATION AND CATALYST RECYCLING IN ONE STEP

摘要

The invention relates to a process for preparing biaryl compounds using Suzuki type coupling reactions of aryl chlorides with aryl boronic acids in presence of a base and a water-soluble transition metal catalyst in a reaction solvent consisting of water/oil/surfactant. The used surfactant is a non-ionic surfactant of 3-6 wt.% (the percentage is related to the total weight of the reaction solvent) and the oil to water ratio in the reaction solvent is from 10:1 to 1:10. Using these reaction conditions a three phases system is formed. The reaction product is isolated from the oil phase. The water phase comprises the formed salts. The catalyst is contained in the surfactant phase being between the oil and water phases. The catalyst is recyclable and reusable.