发明名称 |
NOVEL LOWERED AFFINITY ANTIBODIES AND USES THEREFOR |
摘要 |
The present invention provides novel, rationally designed lowered affinity antibodies for use in various in vivo and in vitro applications. The antibodies of the present invention have variable domains that have been designed to reduce or eliminate the antigen binding activity of the parental antibody without altering the overall 3 dimensional antibody structure. Using the antibodies of the present invention in various assays allows researchers to distinguish effects that result from specific antigen-antibody interactions from other, non-specific antibody effects. |
申请公布号 |
WO2010088522(A3) |
申请公布日期 |
2011.02.24 |
申请号 |
WO2010US22592 |
申请日期 |
2010.01.29 |
申请人 |
AB BIOSCIENCES, INC.;CHANG, HSIU-CHING |
发明人 |
CHANG, HSIU-CHING |
分类号 |
C07K16/28;C12N15/85;G01N33/53 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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