MAGNETIC NANOPARTICLES HAVING NOVEL CORE-SHELL STRUCTURE AND PH RESPONSIVENESS, AND USE THEREOF

摘要

A class of magnetic composite nanoparticles of multilayer core-shell structure having Fe3O4 nanoparticles encapsulated by a triblock copolymer, and use of the composite nanoparticles as drug carriers are provided. The first block of the triblock copolymer is methoxypolyethylene glycol;the second block is a random copolymer of acrylic acid and acrylate, or a random copolymer of methacrylic acid and methacrylate;and the third block is polyglycerol monoacrylate or polyglycerol monomethacrylate. The third block polymer is combined with the surface of Fe3O4 nanoparticles. The drugs having amino group or amine group, such as adriacin can be loaded on a polyanion layer which is outer sublayer of the composite nanoparticles. The loaded drugs will not be released under neutral condition and will be released when pH is under 5.5.