发明名称 |
MIMOTOPES OF HIV AND USES THEREOF |
摘要 |
The invention provides methods, compositions and kits for treating and or preventing diseases having immunological components associated with their etiology and/or progression (e.g., an HIV infection). A mimotope that mimics an epitope of an antigen may be administered to an individual to induce or enhance an immune response for the treatment of a disease. For example, HIV envelope-like polypeptides (wild-type HIV polypeptides and mimotopes) may be administered to an individual so as to induce a protective immune response to HIV. Alternatively, antibodies directed to a mimotope may be administered to an individual to treat or prevent a disease. Antibodies directed to HIV envelope-like polypeptides may be administered to an individual to treat or prevent an HIV infection and/or one or more symptoms associated with the infection (e.g., AIDS). In another embodiment, the invention provides compositions and methods for isolating an epitope specific B cell. |
申请公布号 |
CA2769407(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
CA20102769407 |
申请日期 |
2010.08.23 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
HUMBERT, MICHAEL;RUPRECHT, RUTH M.;SHOLUKH, ANTON M. |
分类号 |
A61K39/395;A61K38/16;A61P31/18;C07K16/10;C12N5/0781;C12N5/10;C12N15/86 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|