发明名称 |
Pyrazole Derivatives as P2X7 Modulators |
摘要 |
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The pyrazole derivatives of formula (I) or salts thereof modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also relates to the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders/diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease.
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申请公布号 |
US2011046137(A1) |
申请公布日期 |
2011.02.24 |
申请号 |
US20080599416 |
申请日期 |
2008.05.08 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
BESWICK PAUL JOHN;CHAMBERS LAURA JANE;CHESSELL IAIN PATRICK;DAVIES DAVID JOHN;DEMONT EMMANUEL HUBERT;GLEAVE ROBERT JAMES;LIVERMORE DAVID GEORGE HUBERT;THEOBALD PAMELA JOAN;VIMAL MYTHILY;WALTER DARYL SIMON |
分类号 |
A61K31/415;A61K31/4178;A61K31/427;A61K31/439;A61K31/4439;A61K31/501;A61K31/506;A61K31/5377;A61P25/28;A61P29/00;C07D231/12;C07D401/04;C07D403/04;C07D403/06;C07D413/06;C07D417/04;C07D471/08 |
主分类号 |
A61K31/415 |
代理机构 |
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地址 |
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