CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS.

摘要

Disclosed herein are compositions and methods for the treatment of otic disorders with apoptosis modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s). A surface seismic survey is generated or obtained from Earth's surface and is based on time in which acoustic waves are reflected to Earth's surface. One or more tools measure density and sonic velocity of a subsurface formation. An estimate of acoustic impedance is obtained from the density and the sonic velocity to generate a synthetic seismic survey. The synthetic seismic survey and the surface seismic survey are compared and/or correlated. The acoustic impedance can be iteratively estimated until the synthetic seismic survey matches the surface seismic survey. Matching the surface seismic survey with the synthetic seismic survey may ensure that the surface seismic survey may be calibrated in actual depth. Disclosed herein are compositions and methods for the treatment of otic disorders with apoptosis modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).