| 发明名称 |
Mutants PF4 polypeptides exhibiting an increased anti-angiogenic activity |
| 摘要 |
<p>The present invention pertains to PF4 muteins which comprise a substitution at position 67, e.g. a L67H substitution, compared to the sequence of the wild-type PF4 protein. Such PF4 muteins exhibit an increased anti-angiogenic activity and a reduced affinity for proteoglycans compared to the wild-type PF4 protein.</p> |
| 申请公布号 |
EP2287183(A1) |
申请公布日期 |
2011.02.23 |
| 申请号 |
EP20090305712 |
申请日期 |
2009.07.29 |
| 申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
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| 分类号 |
C07K14/52;A61K31/713;A61K38/00;A61K38/19;A61K45/06;A61P27/02;A61P35/00 |
主分类号 |
C07K14/52 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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