| 摘要 |
<p>Proteins (A) of the ubiquitin-like protein superfamily that include at least one amino acid (aa) modification, at least in the surface-exposed region of the protein, so as to impart a binding specificity, for a predetermined binding partner, that is not present in the original protein are new. Proteins (A) of the ubiquitin-like protein superfamily that include at least one amino acid (aa) modification, at least in the surface-exposed region of the protein, so as to impart a binding specificity, for a predetermined binding partner, that is not present in the original protein are new. (A), or derived fragments or fusion proteins, retain the ubiquitin-like folding motif of the original protein, and the surface-exposed region includes at least one beta -fold region, optionally also a non-beta -fold region. An independent claim is also included for a method for preparing (A). - ACTIVITY : Cytostatic. No biological data given. - MECHANISM OF ACTION : Receptor or ligand blockade; targeted delivery of other effectors.</p> |
