SIRT1 POLYMORPHIC VARIANTS AND METHODS OF USE THEREOF
摘要
<p>Provided herein are Sirt1 polymorphic variants having a substitution at amino acid residue 107 or nucleotide 373. In certain embodiments, the Sirt1 polypeptide variants have a L107P substitution and the nucleic acid variants have a T373C substitution. Genetic and/or biochemical testing may be performed to identify whether a patient carries one of the disclosed polymorphic variants. Based on the polymorphic variant the patient carries, a medical practitioner may administer an appropriate therapy, such as a sirtuin activator.</p>
申请公布号
EP2285977(A1)
申请公布日期
2011.02.23
申请号
EP20090747643
申请日期
2009.05.15
申请人
SIRTRIS PHARMACEUTICALS, INC.;UNIVERSITY OF ZURICH