发明名称 AQUEOUS LIQUID CONTAINING GATIFLOXACIN, METHOD FOR PRODUCTION THEREOF, AND METHOD FOR PREVENTION OF PRODUCTION OF PRECIPITATES DURING STORAGE OF THE AQUEOUS LIQUID AT LOW TEMPERATURE OR UPON FREEZING/THAWING OF THE AQUEOUS LIQUID.
摘要 <p>Disclosed is an aqueous liquid which comprises gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate of gatifloxacin or the pharmacologically acceptable salt in an amount of 0.65 to 2 w/v% in terms of free gatifloxacin content and at least one member selected from phosphoric acid, malonic acid, nicotinic acid amide or salts thereof in an amount of at least 0.5 w/v% and has a pH value of 5.8 to 6.9. In the aqueous liquid, the solubility of gatifloxacin is increased. When at least one member selected from nicotinic acid amide, caffeine, methylglucamine, methyl paraoxybenzoate and salts thereof is added to the aqueous liquid,the production of precipitates in the aqueous liquid during the storage of the aqueous liquid at a low temperature or freezing/thawing of the aqueous liquid can be prevented.</p>
申请公布号 MX2010010686(A) 申请公布日期 2011.02.23
申请号 MX20100010686 申请日期 2009.03.30
申请人 KYORIN PHARMACEUTICAL CO., LTD. 发明人 SAWA, SHIROU
分类号 A61K31/496;A61P27/02;A61P31/04 主分类号 A61K31/496
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