RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF
摘要
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell.
申请公布号
EP2069380(A4)
申请公布日期
2011.02.23
申请号
EP20070842674
申请日期
2007.09.18
申请人
ALNYLAM PHARMACEUTICALS INC.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM