发明名称 |
An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
摘要 |
The present invention relates to a purified antibody which selectively binds a TRAIL receptor DR4 and shows no binding above 1.5 times background for DR5, DcR1 or DcR2, wherein said antibody, in its soluble form, has in vivo and in vitro apoptosis-inducing activity in target cells expressing DR4, wherein the apoptosis-inducing activity in vitro is characterized by less than 50% target cell viability at antibody concentrations of less than 0.1 µg/ml for use in the treatment of a disease. |
申请公布号 |
EP2287285(A2) |
申请公布日期 |
2011.02.23 |
申请号 |
EP20100011252 |
申请日期 |
2002.11.01 |
申请人 |
UAB RESEARCH FOUNDATION |
发明人 |
ZHOU, TONG;KIMBERLY, ROBERT, P.;KOOPMAN, WILLIAM, J.;LOBUGLIO, ALBERT, F.;BUCHSBAUM, DONALD, J. |
分类号 |
A61K39/395;C12N15/09;A61K31/337;A61K31/519;A61K31/704;A61K41/00;A61K45/00;A61K45/06;A61P3/10;A61P5/44;A61P7/06;A61P9/00;A61P9/10;A61P11/06;A61P13/12;A61P17/00;A61P21/04;A61P25/28;A61P29/00;A61P31/12;A61P35/00;A61P37/00;A61P37/06;A61P37/08;A61P43/00;C07H21/04;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/63;C12P21/06;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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