摘要 |
<p>Humanized antibodies specifically binding to hTNF-alpha are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-alpha-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.</p> |
申请人 |
YUHAN CORPORATION |
发明人 |
YOO, TAE HYOUNG;SONG, MOO YOUNG;KIM, CHANG SEOK;PARK, SANG KOO;NA, KANG IN;LEE, BYUNG KYU;KANG, HEUI IL |