| 摘要 |
It is intended to disclose preparation composition which enable convenient production of sustained-release preparation composition containing acid-unstable physiologically active compound and have the desired sustained-release properties. Namely, preparation composition comprising a core containing an acid-unstable physiologically active compound and a coating with which the core is coated and which contains a mixture of a water-insoluble polymer and an enteric polymer. The preparation composition according to the present invention makes it possible to maintain an effective concentration in blood of the physiologically active compound over a long time, thereby improving its therapeutic effect. Moreover, the composition according to the present invention remains stable over prolonged storage.
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