发明名称 |
Peptides having neutrophil-stimulating activity |
摘要 |
A peptide having a sequence which satisfies all of the following requirements (I) to (V) and has an activity of stimulating an immune cell: (I) the number of constituent amino acid residues is 12 to 36; (II) the sequence is amphipathic; (III) the charge of the whole molecule is +2 or more; (IV) when constituent amino acid residues are arranged so as to form an a-helical structure, a side chain of any aromatic amino acid residue is not located between side chains of at least two positively charged amino acid residues on a side where hydrophilic amino acid residues are located; and (V) the sequence contains an amino acid residue which serves as a cleavage point for a mitochondrial processing enzyme.
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申请公布号 |
US7893199(B2) |
申请公布日期 |
2011.02.22 |
申请号 |
US20070443404 |
申请日期 |
2007.09.28 |
申请人 |
NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY |
发明人 |
MUKAI HIDEHITO;WAKAMATSU KAORI |
分类号 |
A61K38/00;A61K38/04;A61K38/16;A61K39/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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