发明名称 |
Clostridial toxin derivatives able to modify peripheral sensory afferent functions |
摘要 |
This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent according to the invention comprises three Domains B, T and E linked together in the following manner: Domain B-Domain T-Domain E where Domain B is the Binding Domain which binds the agent to a Binding Site on the cell which undergoes endocytosis to produce an endosome, Domain T is the Translocation Domain which translocates the agent (with or without the Binding Site) from within the endosome across the endosomal membrane into the cytosol of the cell, Domain E is the Effector Domain which inhibits the ability of the Recyclable Membrane Vesicles to transport the Integral Membrane Proteins to the surface of the cell.
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申请公布号 |
US7892560(B2) |
申请公布日期 |
2011.02.22 |
申请号 |
US20070819648 |
申请日期 |
2007.06.28 |
申请人 |
SYNTAXIN, LTD |
发明人 |
FOSTER KEITH ALAN;DUGGAN MICHAEL JOHN;SHONE CLIFFORD CHARLES |
分类号 |
A61K38/16;C12N15/09;A61K35/74;A61K38/00;A61K38/18;A61K38/22;A61K38/46;A61K38/48;A61K39/395;A61K47/48;A61P25/00;A61P25/04;C07K14/33;C07K14/48;C07K14/485;C07K19/00;C12N9/52;C12N15/31;C12N15/62;C12P21/02 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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