摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a novel compound - {3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl}thiourea of formula I: ^ , which exhibit antiviral activity towards orthopoxviruses. The compound is obtained through reaction of thiosemicarbazide with 4,4a,5,5a,6,6a-hexahydro-4,6-etheno-1H-cyclopropylisobenzofuran-1,3(3aH)-dione in acetic acid while boiling. Output is equal to 93%. ^ EFFECT: improved properties of the compound, high yeild. ^ 2 tbl, 3 ex |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE UCHREZHDENIE NAUKI "GOSUDARSTVENNYJ NAUCHNYJ TSENTR VIRUSOLOGII I BIOTEKHNOLOGII "VEKTOR" FEDERAL'NOJ SLUZHBY PO NADZORU V SFERE ZASHCHITY PRAV POTREBITELEJ I BLAGOPOLUCHIJA CHELOVEKA (FGUN GNTS VB "VEKTOR" ROSPOTREBNADZOR;NOVOSIBIRSKIJ INSTITUT ORGANICHESKOJ KHIMII IM. N.N. VOROZHTSOVA SIBIRSKOGO OTDELENIJA RAN (NIOKH SO RAN) |
发明人 |
SELIVANOV BORIS ALEKSEEVICH;TIKHONOV ALEKSEJ JAKOVLEVICH;BELANOV EVGENIJ FEDOROVICH;BORMOTOV NIKOLAJ IVANOVICH;BALAKHNIN SERGEJ MARKOVICH;SEROVA OL'GA ALEKSEEVNA;SVJATCHENKO VIKTOR ALEKSANDROVICH;KISELEV NIKOLAJ NIKOLAEVICH;KAZACHINSKAJA ELENA IVANOVNA;LOKTEV VALERIJ BORISOVICH;DROZDOV IL'JA GENNADIEVICH;STAVSKIJ EVGENIJ ALEKSANDROVICH |