MAKROZYKLISCHE HEMMER DES HEPATITIS-C-VIRUS

摘要

Combinations comprising inhibitors of HCV replication of formula (I)
and the N -oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X
is N, CH and where X bears a double bond it is C; R 1
is -OR 7 , -NH-SO 2 R 8 ; R 2
is hydrogen, and where X is C or CH, R 2 may also be C 1-6 alkyl; R 3
is hydrogen, C 1-6 alkyl, C 1-6 alkoxyC 1-6 alkyl, C 3-7 cycloalkyl; R 4
is aryl or Het; n is 3, 4, 5, or 6; R 5
is halo, C 1-6 alkyl, hydroxy, C 1-6 alkoxy, phenyl, or Het; R 6
is C 1-6 alkoxy, or dimethylamino; R 7
is hydrogen; aryl; Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; or C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or with Het; R 8
is aryl; Het; C 3-7 cycloalkyl optionally substituted with C 1-6 alkyl; or C 1-6 alkyl optionally substituted with C 3-7 cycloalkyl, aryl or with Het; aryl
is phenyl optionally substituted with one, two or three substituents; Het
is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents.