| 发明名称 |
METHOD FOR MAKING 3a-HYDROXY, 3ß- METHYL-5a-PREGNAN-20-ONE (GANAXOLONE) |
| 摘要 |
Applicants have discovered a method for the stereoselective and regioselective synthesis of 3a-hydroxy, 3ß-methyl-5a- pregnan-20-one (ganaxolone) comprising reacting 5a-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula. |
| 申请公布号 |
WO2011019821(A2) |
申请公布日期 |
2011.02.17 |
| 申请号 |
WO2010US45176 |
申请日期 |
2010.08.11 |
| 申请人 |
MARINUS PHARMACEUTICALS, INC.;SHAW, KENNETH;HUTCHISON, ALAN |
发明人 |
SHAW, KENNETH;HUTCHISON, ALAN |
| 分类号 |
C07J5/00;A61K31/57;A61K31/575;A61P25/28;C07J9/00 |
主分类号 |
C07J5/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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