发明名称 |
TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING MINIMAL CDRS |
摘要 |
A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region. |
申请公布号 |
WO2011019844(A1) |
申请公布日期 |
2011.02.17 |
申请号 |
WO2010US45210 |
申请日期 |
2010.08.11 |
申请人 |
CRYSTAL BIOSCIENCE INC.;HARRIMAN, WILLIAM DON;ETCHES, ROBERT;LEIGHTON, PHIL |
发明人 |
HARRIMAN, WILLIAM DON;ETCHES, ROBERT;LEIGHTON, PHIL |
分类号 |
A01K67/027;C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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