PHARMACEUTICAL DOSAGE FORM FOR ORAL ADMINISTRATION OF A BCL-2 FAMILY INHIBITOR
摘要
The invention relates to a pharmaceutical dosage form which comprises a solid dispersion product comprising N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-l-cyclohex-l-en- 1-yl)methyl)piperazin- 1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1- ((phenylsulfanyl)methyl) propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide or a salt, hydrate or solvate thereof, at least one pharmaceutically acceptable polymer, and at least one pharmaceutically acceptable solubilizer. The invention is further directed to processes for preparing the pharmaceutical dosage form and to use of the dosage form for treating proliferative disorders.
申请公布号
WO2010143074(A3)
申请公布日期
2011.02.17
申请号
WO2010IB01659
申请日期
2010.06.08
申请人
ABBOTT GMBH & CO. KG;PACKHAEUSER, CLAUDIA;STEIGER, NORBERT;LIEPOLD, BERND;KOSTELAC, DRAZEN;KNOBLOCH, MARTIN
发明人
PACKHAEUSER, CLAUDIA;STEIGER, NORBERT;LIEPOLD, BERND;KOSTELAC, DRAZEN;KNOBLOCH, MARTIN