| 摘要 |
Disclosed is a pharmaceutical composition for suppressing pain in joint disorders, said composition comprising a pharmaceutically allowable carrier and hyaluronic acid crosslinked by means of cyclizing a double bond of the cinnamic acid portion of a partially amidated hyaluronic acid represented by general formula 1, [Ar-CH=CH-COO-(CH2)n-NH-]m-HA (wherein Ar represents a phenyl group that may have substituent groups, n represents 2 or 3, HA represents a carboxyl residue of hyaluronic acid, m represents the proportion of amidated carboxyl groups out of all of the carboxyl groups of hyaluronic acid, and m is 3-50% of all of the carboxyl groups), forming a cyclobutane ring. The pharmaceutical composition is an intra-articularly administered formulation that, after administration, has a rapid analgesic effect, and unlike the conventional plurality of administrations, with only one administration, sustains an extremely long-term effect on human joint disorders. |
