发明名称 |
REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES |
摘要 |
The present invention relates to a method of making pyrimidines of formula (III) wherein X2 is a leaving group selected from the group consisting of: phenyloxy optionally substituted by 1-5 suitable substituents, heterocyclyl N-oxy optionally substituted by 1-5 suitable substituents, and heteroaryl N-oxy optionally substituted by 1-5 suitable substituents; R1 and R2 are substituents independently selected from the group consisting of hydrogen, an aromatic group and an aliphatic group, or taken together -N(R1)R2 can form a 4-11 membered aromatic or aliphatic ring; said method comprising reacting a compound of formula (I) with an amine of formula (Il) [HN(R1)R2] to form a compound of formula (III), wherein X1 is a leaving group. |
申请公布号 |
CA2767965(A1) |
申请公布日期 |
2011.02.17 |
申请号 |
CA20102767965 |
申请日期 |
2010.08.13 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
LINZ, GUENTER;KRAEMER, GERD;KUSSEROW, SABRINA;SCHNAUBELT, JUERGEN |
分类号 |
C07D239/34;C07D239/47;C07D401/12 |
主分类号 |
C07D239/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|