| 摘要 |
Nucleic acid molecules from Cannabis sativa (cannabis, hemp, marijuana) ha/ e been isolated and characterized, and encode polypeptides having aromatic prenyltransferase activiity. Specifically, the enzyme, CsPT1, is a geranylpyrophosphate olivetolate geranyltransferase, active in the cannabinoid biosynthesis step of prenylation of olivetolic acid to form cannabigerolic acid (CBGA). Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds. |
