| 摘要 |
<p>Novel heterocyclically substituted 5-sulphamoylbenzoic acid derivatives of the accompanying formula I, in which the symbols R<1>, R<2>, X and A have the meaning given in Patent Claim 1, are prepared by introducing the X radical into corresponding 3-nitro-5-sulphamoylbenzoic acids or their esters which carry a reactive group in the 4-position and whose 5-sulphamoyl group is protected, reducing the reaction product to the corresponding 3-amino compound, reacting this with dicarboxylic acid derivatives, reducing the 3-imido or 3-amido compounds obtained in this case and hydrolysing the reaction product obtained in this reaction to remove the protective group B and the ester group R<3>. The alkyl radicals R<2> can then be introduced by alkylation. The novel compounds are highly active saluretics and diuretics and can be processed, if appropriate combined with other therapeutics, to give medicaments for use in human and veterinary medicine. They are mainly used for the treatment of oedematous diseases of various origin. <IMAGE></p> |
