| 摘要 |
PURPOSE:To obtain a quinone useful as a drug in high yield by one process, by reacting 2,3-dimethoxy-5-methyl-1,4-benzoquinone with an carboxylic acid under mild conditions, recovering the unreacted raw materials after the reaction without loss. CONSTITUTION:2,3-Dimethoxy-5-methyl-1,4-benzoquinone shown by the formulaI is reacted with a peroxide of a carboxylic acid shown by the formula RCOOH (R is an alkyl having a terminal group which may be protected and OH) or its acid anhydride preferably in an inert solvent at 80-100 deg.C for 0.5-3hr, to give a quinone shown by the formula II. A peroxide of a carboxylic acid anhydride which evolves CO2 under heating and prepares an alkyl radical such as bis(11- acetoxyundecanoyl)peroxide, bis(acetoxyacetyl)peroxide, etc. may be cited as the peroxide of carboxylic acid anhydride. |
