发明名称 Acid addition salts of 5-aminolevulinic acid or its derivatives
摘要 The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.
申请公布号 US7888526(B2) 申请公布日期 2011.02.15
申请号 US20050594361 申请日期 2005.03.29
申请人 PHOTOCURE ASA 发明人 BRAENDEN JON ERIK;GODAL ASLAK;NILSEN NILS OLAV;KLAVENESS JO
分类号 C07C229/22;A61K31/195 主分类号 C07C229/22
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