发明名称 |
Process for the preparation of dihydroxy esters and derivatives thereof |
摘要 |
A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group. |
申请公布号 |
US7888083(B2) |
申请公布日期 |
2011.02.15 |
申请号 |
US20100768459 |
申请日期 |
2010.04.27 |
申请人 |
ASTRAZENECA UK LIMITED |
发明人 |
BLACKER ANDREW JOHN;REEVE CHRISTOPHER DAVID;HOLT ROBERT ANTONY |
分类号 |
C12P7/62;C07C67/03;C07C69/66;C07C69/675;C07D319/06;C12N9/14;C12N9/20;C12P17/06;C12R1/84 |
主分类号 |
C12P7/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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