发明名称 |
Live attenuated Leishmania vaccines |
摘要 |
Targeted disruption of the centrin gene leads to attenuation of growth in Leishmania. Preferred embodiments of the invention provide attenuated strains of Leishmania useful for the preparation of immunogenic preparations including vaccines against a disease caused by infection with a virulent Leishmania strain and as tools for the generation of immunological and diagnostic reagents. Other preferred embodiments provide related immunogenic compositions, methods of generating an immune response, methods for producing a vaccine, and methods of forming attenuated strains of Leishmania. |
申请公布号 |
US7887812(B2) |
申请公布日期 |
2011.02.15 |
申请号 |
US20060364682 |
申请日期 |
2006.02.28 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
NAKHASI HIRA L.;SELVAPANDIYAN ANGAMUTHU;DEBRABANT ALAIN;DUNCAN ROBERT C.;SALOTRA POONAM;SREENIVAS GANNAVARAM |
分类号 |
A61K39/02;A61K39/008;C12N1/36 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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